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Target
Guanylate cyclase soluble subunit alpha-1
Ligand
BDBM463297
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.378±n/a nM
Citation
 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators US Patent  US10780092 Publication Date 9/22/2020 
Target
Name:
Guanylate cyclase soluble subunit alpha-1
Synonyms:
GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC)
Type:
Enzyme
Mol. Mass.:
77457.21
Organism:
Homo sapiens (Human)
Description:
Q02108
Residue:
690
Sequence:
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
  
Inhibitor
Name:
BDBM463297
Synonyms:
4-amino-2-(8-{2- fluorobenzyl}imidazo- [1,2-a]pyrazin-6-yl)- 5-(4-hydroxy-5- (trifluoromethyl)- pyridin-2-yl)-5-methyl- 5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one | US10780092, Example 146-B
Type:
Small organic molecule
Emp. Form.:
C26H18F4N8O2
Mol. Mass.:
550.4671
SMILES:
CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(cn1)C(F)(F)F
Structure:
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