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Target
Free fatty acid receptor 2
Ligand
BDBM404212
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
1500±n/a nM
Citation
 Hoveyda, HR; Schils, D; Zoute, L; Parcq, J Substituted pyrrolidines as G-protein coupled receptor 43 agonists US Patent  US10781171 Publication Date 9/22/2020 
Target
Name:
Free fatty acid receptor 2
Synonyms:
FFA2 | FFAR2 | FFAR2_HUMAN | G-protein coupled receptor 43 | GPCR43 | GPR43
Type:
PROTEIN
Mol. Mass.:
37156.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508993
Residue:
330
Sequence:
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
  
Inhibitor
Name:
BDBM404212
Synonyms:
(2S,5R)-5-(2-chlorophenyl)-1-(2'-cyano-4'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid | US10017468, Compound 387 | US10781171, Compound 378
Type:
Small organic molecule
Emp. Form.:
C28H33ClN4O7S
Mol. Mass.:
605.102
SMILES:
OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCN(CC1)c1ccc(cc1[N+]([O-])=O)S(=O)(=O)N1CCCCC1)c1ccccc1Cl
Structure:
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