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Target5-hydroxytryptamine receptor 2A
LigandBDBM463328
Substrate/Competitorn/a
Meas. Tech.[125I]DOI Radioligand Binding Assay
IC50 1.10±n/a nM
Citation Teegarden, BXiong, YStrah-Pleynet, SJayakumar, HDosa, PIFeichtinger, KCasper, MLehmann, JJones, RMUnett, DJChoi, JS 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto US Patent US10781180 Publication Date 9/22/2020
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 2A
Name:5-hydroxytryptamine receptor 2A
Synonyms:5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | HTR2 | HTR2A | Serotonin receptor 2A
Type:undefined
Mol. Mass.:52607.65
Organism:Homo sapiens (Human)
Description:P28223
Residue:471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM463328
NameBDBM463328
Synonyms: [3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-carbamic acid isobutyl ester | US10781180, Compound 23
TypeSmall organic molecule
Emp. Form.C21H29BrN4O3
Mol. Mass.465.384
SMILESCCC(C)OC(=O)Nc1ccc(OCCN2CCCC2)c(c1)-c1c(Br)cnn1C |(-4,6.93,;-2.67,6.16,;-1.33,6.93,;-1.33,8.47,;,6.16,;,4.62,;-1.33,3.85,;1.33,3.85,;1.33,2.31,;,1.54,;;1.33,-.77,;1.33,-2.31,;0,-3.08,;-1.33,-2.31,;-2.67,-3.08,;-4.07,-2.45,;-5.1,-3.6,;-4.33,-4.93,;-2.83,-4.61,;2.67,,;2.67,1.54,;4,-.77,;5.41,-.14,;5.73,1.36,;6.44,-1.29,;5.67,-2.62,;4.16,-2.3,;3.02,-3.33,)|
Structure
n/a