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Target
Non-receptor tyrosine-protein kinase TYK2
Ligand
BDBM463744
Substrate
n/a
Meas. Tech.
Caliper Assay
Ki
5±n/a nM
Citation
 Masse, CE; Greenwood, JR; Romero, DL; Harriman, GC; Wester, RT; Shelley, M; Kennedy-Smith, JJ; Dahlgren, M; Mondal, S; Robinson, S TYK2 inhibitors and uses thereof US Patent  US10781204 Publication Date 9/22/2020 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2
Type:
Protein
Mol. Mass.:
133666.03
Organism:
Homo sapiens (Human)
Description:
P29597
Residue:
1187
Sequence:
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM463744
Synonyms:
US10781204, Compound I-221 | US11434240, Compound I-221
Type:
Small organic molecule
Emp. Form.:
C24H21FN6O4
Mol. Mass.:
476.4597
SMILES:
O[C@H]1CO[C@@]2(CCN(C2)c2ccn(n2)-c2cc(nc3CNC(=O)c23)-c2c(F)cccc2C#N)OC1 |r,wU:1.0,wD:4.8,(-2.95,8.98,;-3.27,7.47,;-2.12,6.44,;-2.44,4.93,;-3.91,4.46,;-5.31,3.83,;-5.15,2.3,;-3.65,1.98,;-2.88,3.31,;-3.02,.57,;-3.79,-.76,;-2.76,-1.9,;-1.35,-1.28,;-1.51,.25,;-.02,-2.05,;-.02,-3.59,;1.31,-4.36,;2.65,-3.59,;2.65,-2.05,;3.79,-1.02,;3.17,.39,;1.63,.23,;.6,1.37,;1.31,-1.28,;1.31,-5.9,;-.02,-6.67,;-1.35,-5.9,;-.02,-8.21,;1.31,-8.98,;2.65,-8.21,;2.7,-6.64,;4.03,-5.87,;5.36,-5.1,;-5.05,5.49,;-4.73,7,)|
Structure:
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