Target
Monoglyceride lipase
Ligand
BDBM280678
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling Assay
IC50
<100±n/a nM
Citation
 Buzard, DJShaghafi, MBCisar, JSGrice, CAJones, TKWeber, OD Spirocycle compounds and methods of making and using same US Patent  US10781211 Publication Date 9/22/2020 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM280678
Synonyms:
US10030020, Example 230 | US10781211, Example 230
Type:
Small organic molecule
Emp. Form.:
C26H30F9N3O4
Mol. Mass.:
619.5197
SMILES:
CC1(CCN(C1)c1cc(ccc1CN1CCCC11CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F)C(O)=O
Structure:
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