Reaction Details Report a problem with these data
Target
Ataxin-1
Ligand
BDBM464385
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
120±n/a nM
Citation
Di Giorgio, P; Hert, J; Hunziker, D; Mattei, P; Rudolph, M; Schmitz, P Bicyclic compounds as ATX inhibitors US Patent US10787459 Publication Date 9/29/2020
More Info.:
Target
Name:
Ataxin-1
Synonyms:
ATX1 | ATX1_HUMAN | ATXN1 | SCA1
Type:
Protein
Mol. Mass.:
86941.25
Organism:
Homo sapiens (Human)
Description:
P54253
Residue:
815
Sequence:
MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
Inhibitor
Name:
BDBM464385
Synonyms:
US10787459, Example 2.00 | US10787459, Example 2.01 | US10787459, Example 2.02 | US10787459, Example 2.03
Type:
Small organic molecule
Emp. Form.:
C28H37N7O5
Mol. Mass.:
551.6373
SMILES:
CO[C@@]12CN(C[C@H]1CN(C2)C(=O)c1cc(OCC2CCOCC2)nc(c1)C1CC1)C(=O)N1CCc2[nH]nnc2C1 |r|