Reaction Details Report a problem with these data
Target
Amino acid transporter
Ligand
BDBM464404
Substrate
n/a
Meas. Tech.
3H-Amino Acid Uptake Assays
IC50
33800±n/a nM
Citation
 Manning, HC; Schulte, M Glutamine transport inhibitors and methods for treating cancer US Patent  US10793514 Publication Date 10/6/2020 
Target
Name:
Amino acid transporter
Synonyms:
Amino acid transporter | Slc1a5
Type:
PROTEIN
Mol. Mass.:
56758.53
Organism:
Rattus norvegicus
Description:
ChEMBL_109757
Residue:
539
Sequence:
MAVDPPKADPKGVVAVDPTANCGSGLKSREDQGAKAGGCCSSRDQVCRCLRANLLVLLTVAAAVAGVVLGLGVSAAGGAEALGHARFTAFAFPGELLLRLLEMIILPLVVCSLIGGAASLDPSALGRLGAWALLFFLVTTLLSSALGVALALALKPGAAFAAINSSVVDSSVHRAPTKEVLDSFLELLRNMFPSNLVSASAAFRIPCGACPQRSNATMDQPHCEMKMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPIGILFLVAGKIVEMKDIRQLFIGLGKYIVCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGMSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAISLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSYVDRTKMPSSEPELIQVKNDVSLKPLPLATEEGNPLLKQCREPSGDSSATCEKESVM
  
Inhibitor
Name:
BDBM464404
Synonyms:
US10793514, Compound 8
Type:
Small organic molecule
Emp. Form.:
C30H28F2N2O4
Mol. Mass.:
518.5511
SMILES:
N[C@H](CCN(Cc1ccccc1Oc1ccccc1F)Cc1ccccc1Oc1ccccc1F)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: