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Target
Amino acid transporter
Ligand
BDBM464411
Substrate
n/a
Meas. Tech.
3H-Amino Acid Uptake Assays
IC50
50800±n/a nM
Citation
 Manning, HC; Schulte, M Glutamine transport inhibitors and methods for treating cancer US Patent  US10793514 Publication Date 10/6/2020 
Target
Name:
Amino acid transporter
Synonyms:
Amino acid transporter | Slc1a5
Type:
PROTEIN
Mol. Mass.:
56758.53
Organism:
Rattus norvegicus
Description:
ChEMBL_109757
Residue:
539
Sequence:
MAVDPPKADPKGVVAVDPTANCGSGLKSREDQGAKAGGCCSSRDQVCRCLRANLLVLLTVAAAVAGVVLGLGVSAAGGAEALGHARFTAFAFPGELLLRLLEMIILPLVVCSLIGGAASLDPSALGRLGAWALLFFLVTTLLSSALGVALALALKPGAAFAAINSSVVDSSVHRAPTKEVLDSFLELLRNMFPSNLVSASAAFRIPCGACPQRSNATMDQPHCEMKMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPIGILFLVAGKIVEMKDIRQLFIGLGKYIVCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGMSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAISLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSYVDRTKMPSSEPELIQVKNDVSLKPLPLATEEGNPLLKQCREPSGDSSATCEKESVM
  
Inhibitor
Name:
BDBM464411
Synonyms:
US10793514, Compound 14
Type:
Small organic molecule
Emp. Form.:
C32H33ClN2O5
Mol. Mass.:
561.068
SMILES:
N[C@H](CCN(Cc1ccccc1OCc1cccc(O)c1)Cc1ccccc1OCc1cccc(Cl)c1)C(O)=O |r|
Structure:
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