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Target
Neutral amino acid transporter B(0)
Ligand
BDBM464414
Substrate
n/a
Meas. Tech.
3H-Amino Acid Uptake Assays
IC50
20100±n/a nM
Citation
 Manning, HC; Schulte, M Glutamine transport inhibitors and methods for treating cancer US Patent  US10793514 Publication Date 10/6/2020 
Target
Name:
Neutral amino acid transporter B(0)
Synonyms:
AAAT_HUMAN | ASCT2 | ASCT2 | ATB(0) | Baboon M7 virus receptor | M7V1 | Neutral amino acid transporter B(0) | RD114/simian type D retrovirus receptor | RDR | RDRC | SLC1A5 | Sodium-dependent neutral amino acid transporter type 2 | Solute carrier family 1 member 5
Type:
PROTEIN
Mol. Mass.:
56592.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109758
Residue:
541
Sequence:
MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESVM
  
Inhibitor
Name:
BDBM464414
Synonyms:
US10793514, Compound 15
Type:
Small organic molecule
Emp. Form.:
C32H32Cl2N2O4
Mol. Mass.:
579.513
SMILES:
N[C@H](CCN(Cc1ccccc1OCc1ccc(Cl)cc1)Cc1ccccc1OCc1ccc(Cl)cc1)C(O)=O |r|
Structure:
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