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Target
Mu-type opioid receptor
Ligand
BDBM464435
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
46.5±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793528 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464435
Synonyms:
US10793528, Example SC_5005
Type:
Small organic molecule
Emp. Form.:
C30H41N5O3
Mol. Mass.:
519.6782
SMILES:
COc1cnccc1NC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O |r,wU:15.32,18.22,(-5.83,5.18,;-5.69,3.65,;-6.95,2.76,;-8.35,3.41,;-9.61,2.53,;-9.47,1,;-8.08,.35,;-6.82,1.23,;-5.42,.58,;-4.16,1.46,;-4.3,3,;-2.76,.82,;-1.5,1.7,;-.11,1.05,;1.24,1.8,;2.37,.75,;3.46,-.34,;4.94,.06,;5.34,1.55,;4.25,2.63,;2.77,2.24,;6.11,2.88,;5.34,4.21,;7.65,2.88,;6.76,.96,;6.97,-.57,;8.39,-1.16,;9.61,-.22,;9.41,1.3,;7.99,1.89,;1.72,-.65,;2.46,-1.99,;1.67,-3.31,;.18,-3.69,;.55,-5.18,;2.05,-4.81,;.19,-.46,;-.86,-1.59,)|
Structure:
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