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Target
Mu-type opioid receptor
Ligand
BDBM464467
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
40.0±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793528 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464467
Synonyms:
US10793528, Example SC_5037
Type:
Small organic molecule
Emp. Form.:
C29H39N5O3
Mol. Mass.:
505.6517
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3ccncc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:3.2,6.23,(8.1,1.67,;6.56,1.67,;5.79,3,;5.79,.33,;5.02,-1,;3.48,-1,;2.71,.33,;1.8,1.58,;.34,1.1,;-.91,2.01,;-2.32,1.38,;-3.56,2.29,;-3.4,3.82,;-4.97,1.66,;-6.21,2.57,;-6.05,4.1,;-7.3,5,;-8.71,4.38,;-8.87,2.85,;-7.62,1.94,;.34,-.44,;-.91,-1.34,;1.8,-.91,;2.28,-2.38,;1.19,-3.46,;2.61,-4.05,;-.35,-3.46,;-.35,-5,;1.19,-5,;3.48,1.67,;5.02,1.67,;6.56,-1,;5.79,-2.33,;6.56,-3.67,;8.1,-3.67,;8.87,-2.33,;8.1,-1,)|
Structure:
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