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Target
Mu-type opioid receptor
Ligand
BDBM464473
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
210±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793528 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464473
Synonyms:
US10793528, Example SC_5043
Type:
Small organic molecule
Emp. Form.:
C25H39N5O4
Mol. Mass.:
473.6083
SMILES:
COCCCN1C(=O)N(CCC(=O)NCC(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1 |r,wU:19.19,22.26,(.76,-5.54,;.76,-4,;1.79,-2.86,;1.31,-1.39,;2.34,-.25,;1.87,1.22,;.4,1.69,;-.84,.79,;.4,3.23,;-.93,4,;-2.26,3.23,;-3.6,4,;-3.6,5.54,;-4.93,3.23,;-6.27,4,;-7.6,3.23,;-8.93,4,;-7.6,1.69,;1.87,3.71,;2.77,2.46,;3.54,1.13,;5.08,1.13,;5.85,2.46,;5.08,3.8,;3.54,3.8,;6.62,3.8,;8.16,3.8,;5.85,5.13,;6.62,1.13,;5.85,-.21,;6.62,-1.54,;8.16,-1.54,;8.93,-.21,;8.16,1.13,)|
Structure:
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