Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464485
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
74.0±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793528 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464485
Synonyms:
US10793528, Example SC_5055
Type:
Small organic molecule
Emp. Form.:
C27H40N4O4
Mol. Mass.:
484.6309
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CCC(=O)NC3COC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:6.21,3.2,(5.34,3.46,;6.11,2.13,;7.65,2.13,;5.34,.79,;4.57,-.54,;3.03,-.54,;2.26,.79,;1.36,2.04,;-.11,1.56,;-1.35,2.47,;-2.76,1.84,;-4.01,2.75,;-3.85,4.28,;-5.41,2.12,;-6.66,3.03,;-6.9,4.55,;-8.42,4.31,;-8.18,2.78,;-.11,.02,;-1.35,-.88,;1.36,-.45,;1.83,-1.92,;.74,-3.01,;2.17,-3.6,;-.8,-3.01,;-.8,-4.55,;.74,-4.55,;3.03,2.13,;4.57,2.13,;6.11,-.54,;5.34,-1.87,;6.11,-3.21,;7.65,-3.21,;8.42,-1.87,;7.65,-.54,)|
Structure:
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