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Target
Mu-type opioid receptor
Ligand
BDBM464499
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
2615±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793528 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464499
Synonyms:
US10793528, Example SC_5074
Type:
Small organic molecule
Emp. Form.:
C27H42N4O3
Mol. Mass.:
470.6474
SMILES:
CCN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:7.19,4.3,(4.61,4.74,;3.84,3.4,;4.61,2.07,;6.15,2.07,;3.84,.74,;3.07,-.6,;1.53,-.6,;.76,.74,;-.15,1.98,;-1.61,1.51,;-2.86,2.41,;-4.26,1.79,;-4.43,.25,;-5.67,1.16,;-5.51,2.69,;-6.92,2.06,;-5.35,4.22,;-1.61,-.03,;-2.86,-.94,;-.15,-.51,;.33,-1.97,;-.7,-3.12,;-1.37,-1.73,;-2.24,-3.2,;-2.16,-4.74,;-.62,-4.66,;1.53,2.07,;3.07,2.07,;4.61,-.6,;3.84,-1.93,;4.61,-3.26,;6.15,-3.26,;6.92,-1.93,;6.15,-.6,)|
Structure:
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