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Target
Mu-type opioid receptor
Ligand
BDBM464505
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
4025±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793528 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464505
Synonyms:
US10793528, Example SC_5081
Type:
Small organic molecule
Emp. Form.:
C26H40N4O3
Mol. Mass.:
456.6208
SMILES:
CN(C)[C@@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:3.2,wD:6.18,(6.19,1.34,;4.77,1.93,;4.57,3.46,;3.54,.99,;2.77,2.33,;1.23,2.33,;.46,.99,;-.44,2.24,;-1.9,1.76,;-3.15,2.67,;-4.56,2.04,;-5.33,.71,;-4.16,.56,;-5.8,2.95,;-7.21,2.32,;-5.64,4.48,;-1.9,.22,;-3.15,-.68,;-.44,-.25,;.04,-1.72,;-.99,-2.86,;.49,-3.26,;-2.53,-2.94,;-2.45,-4.48,;-.91,-4.4,;1.23,-.34,;2.77,-.34,;4.63,-.1,;4.24,-1.58,;5.32,-2.67,;6.81,-2.27,;7.21,-.79,;6.12,.3,)|
Structure:
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