Target
Prostacyclin receptor
Ligand
BDBM464509
Substrate
n/a
Meas. Tech.
HTRF assay
EC50
8.00±n/a nM
Citation
 Tran, THayashi, RIbarra, JBUllman, BZou, N Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators US Patent  US10793529 Publication Date 10/6/2020 
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Homo sapiens (Human)
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM464509
Synonyms:
2-(((1s,4s)-4-((6-(4- methoxyphenyl)-3-oxo-5- phenyl-1,2,4-triazin-2(3H)- yl)methyl)cyclohexyl) methoxy)acetic acid | US10793529, Compound 69
Type:
Small organic molecule
Emp. Form.:
C26H29N3O5
Mol. Mass.:
463.5256
SMILES:
COc1ccc(cc1)-c1nn(C[C@@H]2CC[C@H](COCC(O)=O)CC2)c(=O)nc1-c1ccccc1 |r,wU:12.12,15.16,(-10,4.62,;-10,3.08,;-8.67,2.31,;-7.34,3.08,;-6,2.31,;-6,.77,;-7.34,,;-8.67,.77,;-4.67,,;-3.33,.77,;-2,,;-.67,.77,;.67,,;.67,-1.54,;2,-2.31,;3.33,-1.54,;4.67,-2.31,;6,-1.54,;7.34,-2.31,;8.67,-1.54,;10,-2.31,;8.67,,;3.33,,;2,.77,;-2,-1.54,;-.67,-2.31,;-3.33,-2.31,;-4.67,-1.54,;-6,-2.31,;-7.34,-1.54,;-8.67,-2.31,;-8.67,-3.85,;-7.34,-4.62,;-6,-3.85,)|
Structure:
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