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Target
Prostacyclin receptor
Ligand
BDBM464511
Substrate
n/a
Meas. Tech.
HTRF assay
EC50
36.0±n/a nM
Citation
 Tran, T; Hayashi, R; Ibarra, JB; Ullman, B; Zou, N Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators US Patent  US10793529 Publication Date 10/6/2020 
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Homo sapiens (Human)
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM464511
Synonyms:
2-(((1s,4s)-4-((3-oxo-5,6-di- p-tolyl-1,2,4-triazin-2(3H)- yl)methyl)cyclohexyl) methoxy)acetic acid | US10793529, Compound 43
Type:
Small organic molecule
Emp. Form.:
C27H31N3O4
Mol. Mass.:
461.5527
SMILES:
Cc1ccc(cc1)-c1nn(C[C@@H]2CC[C@H](COCC(O)=O)CC2)c(=O)nc1-c1ccc(C)cc1 |r,wU:11.11,14.15,(-10,3.85,;-8.67,3.08,;-7.34,3.85,;-6,3.08,;-6,1.54,;-7.34,.77,;-8.67,1.54,;-4.67,.77,;-3.33,1.54,;-2,.77,;-.67,1.54,;.67,.77,;.67,-.77,;2,-1.54,;3.33,-.77,;4.67,-1.54,;6,-.77,;7.34,-1.54,;8.67,-.77,;10,-1.54,;8.67,.77,;3.33,.77,;2,1.54,;-2,-.77,;-.67,-1.54,;-3.33,-1.54,;-4.67,-.77,;-6,-1.54,;-7.34,-.77,;-8.67,-1.54,;-8.67,-3.08,;-10,-3.85,;-7.34,-3.85,;-6,-3.08,)|
Structure:
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