Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM464582
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
28.0±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM464582
Synonyms:
CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-[2-[2-[2-(2-methoxy-ethoxy)- ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4002
Type:
Small organic molecule
Emp. Form.:
C34H57N3O7
Mol. Mass.:
619.8323
SMILES:
COCCOCCOCCOCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O |r,wU:21.37,24.27,(-22.94,-2.97,;-21.6,-3.74,;-20.27,-2.97,;-18.94,-3.74,;-17.6,-2.97,;-16.27,-3.74,;-14.93,-2.97,;-13.6,-3.74,;-12.27,-2.97,;-10.93,-3.74,;-9.6,-2.97,;-8.27,-3.74,;-6.93,-2.97,;-5.6,-3.74,;-4.26,-2.97,;-2.93,-3.74,;-1.6,-2.97,;-.26,-3.74,;1.07,-2.97,;2.4,-3.74,;3.87,-3.26,;4.77,-4.51,;5.54,-5.84,;7.08,-5.84,;7.85,-4.51,;7.08,-3.18,;5.54,-3.18,;8.62,-3.18,;7.85,-1.84,;10.16,-3.18,;8.62,-5.84,;7.85,-7.18,;8.62,-8.51,;10.16,-8.51,;10.93,-7.18,;10.16,-5.84,;3.87,-5.76,;4.34,-7.22,;3.31,-8.37,;1.77,-8.37,;1.77,-9.91,;3.31,-9.91,;2.4,-5.28,;1.16,-6.19,)|
Structure:
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