Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM464588
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
7.30±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM464588
Synonyms:
CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-[2-(2-methoxy-ethoxy)- ethoxy]-ethoxy]-ethyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4008
Type:
Small organic molecule
Emp. Form.:
C30H49N3O5
Mol. Mass.:
531.7272
SMILES:
COCCOCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O |r,wU:18.21,15.31,(-12.83,8.2,;-11.74,7.11,;-10.26,7.51,;-9.17,6.42,;-7.68,6.82,;-6.59,5.73,;-5.1,6.13,;-4.01,5.04,;-2.53,5.44,;-1.44,4.35,;.05,4.75,;1.14,3.66,;2.63,4.06,;3.72,2.97,;5.18,3.44,;6.09,2.2,;6.86,.86,;8.4,.86,;9.17,2.2,;8.4,3.53,;6.86,3.53,;10.26,3.29,;11.74,2.89,;9.86,4.77,;10.26,1.11,;9.86,-.38,;10.95,-1.47,;12.43,-1.07,;12.83,.42,;11.74,1.51,;5.18,.95,;5.66,-.51,;4.63,-1.66,;3.14,-2.06,;3.54,-3.54,;5.03,-3.15,;3.72,1.43,;2.47,.52,)|
Structure:
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