Target
Nociceptin receptor
Ligand
BDBM464592
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
1.60±n/a nM
Citation
 Kuehnert, SKoenigs, RMKless, AWegert, ARatcliffe, PJostock, RKoch, TLinz, KSchroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM464592
Synonyms:
CIS-4-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-butyronitrile | US10793556, Example SC_4012
Type:
Small organic molecule
Emp. Form.:
C25H36N4O
Mol. Mass.:
408.5795
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CCCC#N)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.16,3.2,(6.97,-2.18,;7.74,-3.52,;9.28,-3.52,;6.97,-4.85,;6.2,-6.19,;4.66,-6.19,;3.89,-4.85,;2.98,-3.61,;1.52,-4.08,;.43,-2.99,;-1.06,-3.39,;-2.15,-2.3,;-3.63,-2.7,;-5.12,-3.1,;1.52,-5.62,;.27,-6.53,;2.98,-6.1,;3.46,-7.56,;2.43,-8.71,;.89,-8.71,;.89,-10.25,;2.43,-10.25,;4.66,-3.52,;6.2,-3.52,;7.74,-6.19,;6.97,-7.52,;7.74,-8.85,;9.28,-8.85,;10.05,-7.52,;9.28,-6.19,)|
Structure:
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