Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464594
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
84.0±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464594
Synonyms:
CIS-3-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-2,2-dimethyl-propionitrile | US10793556, Example SC_4014
Type:
Small organic molecule
Emp. Form.:
C26H38N4O
Mol. Mass.:
422.6061
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:3.2,6.17,(11.4,-20.19,;9.91,-19.79,;9.51,-18.3,;8.82,-20.88,;8.05,-22.21,;6.51,-22.21,;5.74,-20.88,;4.84,-19.63,;3.37,-20.11,;2.28,-19.02,;.79,-19.42,;.4,-20.91,;1.88,-20.51,;-.29,-18.33,;-1.38,-17.24,;3.37,-21.65,;2.13,-22.55,;4.84,-22.12,;5.31,-23.59,;4.28,-24.73,;2.79,-25.13,;3.19,-26.62,;4.68,-26.22,;6.51,-19.55,;8.05,-19.55,;9.91,-21.97,;9.51,-23.46,;10.6,-24.54,;12.09,-24.15,;12.49,-22.66,;11.4,-21.57,)|
Structure:
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