Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464598
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
206±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464598
Synonyms:
CIS-3-[1-[(1-Hydroxy-cyclobutyl)-methyl]-8-methylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-propionitrile | US10793556, Example SC_4022 | US10793556, Example SC_4024 | US10793556, Example SC_4025 | US10793556, Example SC_4026
Type:
Small organic molecule
Emp. Form.:
C27H42N4O3
Mol. Mass.:
470.6474
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CCN3CCOCC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:3.2,6.20,(4.7,-19.56,;5.1,-21.04,;6.59,-21.44,;4.01,-22.13,;3.24,-23.47,;1.7,-23.47,;.93,-22.13,;.03,-20.89,;-1.44,-21.36,;-2.53,-20.27,;-4.01,-20.67,;-5.1,-19.58,;-4.7,-18.1,;-5.79,-17.01,;-7.28,-17.41,;-7.68,-18.89,;-6.59,-19.98,;-1.44,-22.9,;-2.68,-23.81,;.03,-23.38,;.5,-24.84,;-.53,-25.99,;1.01,-25.99,;-2.01,-26.39,;-1.62,-27.87,;-.13,-27.48,;1.7,-20.8,;3.24,-20.8,;5.1,-23.22,;4.7,-24.71,;5.79,-25.8,;7.28,-25.4,;7.68,-23.91,;6.59,-22.82,)|
Structure:
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