Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM464602
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
119±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM464602
Synonyms:
CIS-3-Acetyl-8-dimethylamino-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4031 | US10793556, Example SC_4032
Type:
Small organic molecule
Emp. Form.:
C26H39N3O3
Mol. Mass.:
441.6062
SMILES:
COC(=O)CCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O |r,wU:12.15,9.25,(-8.42,19.13,;-6.93,19.53,;-5.85,18.44,;-6.24,16.95,;-4.36,18.84,;-3.27,17.75,;-1.78,18.15,;-.69,17.06,;.77,17.54,;1.68,16.29,;2.45,14.96,;3.99,14.96,;4.76,16.29,;3.99,17.62,;2.45,17.62,;5.85,17.38,;5.45,18.87,;7.33,16.98,;5.85,15.2,;5.45,13.71,;6.54,12.63,;8.02,13.02,;8.42,14.51,;7.33,15.6,;.77,15.05,;1.25,13.58,;.22,12.44,;-1.27,12.04,;-.87,10.55,;.62,10.95,;-.69,15.52,;-1.94,14.62,)|
Structure:
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