Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464605
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
1290±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464605
Synonyms:
CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-methylsulfonyl-ethyl)-8- phenyl-1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4034 | US10793556, Example SC_4035 | US10793556, Example SC_4036 | US10793556, Example SC_4037 | US10793556, Example SC_4038 | US10793556, Example SC_4039
Type:
Small organic molecule
Emp. Form.:
C27H41N3O4S
Mol. Mass.:
503.697
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:6.21,3.2,(7.13,-24.56,;5.79,-23.79,;5.79,-22.25,;4.7,-24.88,;3.93,-26.21,;2.39,-26.21,;1.62,-24.88,;.72,-23.63,;-.75,-24.11,;-1.83,-23.02,;-3.32,-23.42,;-4.41,-22.33,;-5.9,-22.73,;-6.3,-24.22,;-7.78,-23.82,;-7.07,-25.55,;-5.21,-25.31,;-3.72,-24.91,;-.75,-25.65,;-1.99,-26.55,;.72,-26.13,;1.2,-27.59,;.16,-28.73,;1.65,-29.13,;-1.38,-28.73,;-1.38,-30.27,;.16,-30.27,;2.39,-23.55,;3.93,-23.55,;5.47,-26.21,;4.7,-27.55,;5.47,-28.88,;7.01,-28.88,;7.78,-27.55,;7.01,-26.21,)|
Structure:
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