Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464611
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
290±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464611
Synonyms:
CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-phenyl-3-tetrahydro-pyran-4-yl- 1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4040 | US10793556, Example SC_4041 | US10793556, Example SC_4042 | US10793556, Example SC_4043
Type:
Small organic molecule
Emp. Form.:
C27H41N3O4S
Mol. Mass.:
503.697
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.22,3.2,(3.96,.41,;4.73,-.92,;6.27,-.92,;3.96,-2.25,;3.19,-3.59,;1.65,-3.59,;.88,-2.25,;-.02,-1.01,;-1.49,-1.48,;-2.82,-.71,;-2.82,.83,;-1.49,1.6,;-2.82,2.37,;-4.16,3.14,;-5.49,2.37,;-6.26,3.7,;-7.03,2.37,;-5.49,.83,;-4.16,.06,;-1.49,-3.02,;-2.73,-3.93,;-.02,-3.5,;.45,-4.96,;-.58,-6.11,;-2.12,-6.11,;-2.12,-7.65,;-.58,-7.65,;1.65,-.92,;3.19,-.92,;4.73,-3.59,;3.96,-4.92,;4.73,-6.25,;6.27,-6.25,;7.04,-4.92,;6.27,-3.59,)|
Structure:
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