Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464615
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
265±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464615
Synonyms:
CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-methyl]-3-[(4-hydroxy- tetrahydro-pyran-4-yl)-methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4044 | US10793556, Example SC_4045 | US10793556, Example SC_4046 | US10793556, Example SC_4047 | US10793556, Example SC_4048
Type:
Small organic molecule
Emp. Form.:
C27H41N3O5S
Mol. Mass.:
519.697
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:6.22,3.2,(4.04,15.98,;4.81,14.65,;6.35,14.65,;4.04,13.32,;3.27,11.98,;1.73,11.98,;.96,13.32,;.06,14.56,;-1.41,14.09,;-2.74,14.86,;-2.74,16.4,;-1.41,17.17,;-2.74,17.94,;-4.07,18.71,;-5.41,17.94,;-6.18,19.27,;-6.9,17.54,;-5.41,16.4,;-4.07,15.63,;-1.41,12.55,;-2.65,11.64,;.06,12.07,;.53,10.61,;-.5,9.46,;.99,9.06,;-2.04,9.46,;-2.04,7.92,;-.5,7.92,;1.73,14.65,;3.27,14.65,;4.81,11.98,;4.04,10.65,;4.81,9.32,;6.35,9.32,;7.12,10.65,;6.35,11.98,)|
Structure:
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