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Target
Mu-type opioid receptor
Ligand
BDBM464626
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
540±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464626
Synonyms:
CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-phenyl-3-piperidin-4-yl-1,3- diazaspiro[4.5]decan-2-one | US10793556, Example SC_4054 | US10793556, Example SC_4055 | US10793556, Example SC_4056 | US10793556, Example SC_4057 | US10793556, Example SC_4058
Type:
Small organic molecule
Emp. Form.:
C29H40N6O
Mol. Mass.:
488.6675
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1 |r,wU:6.25,3.2,(7.35,2.01,;5.86,2.41,;5.86,3.95,;4.78,1.32,;4.01,-.01,;2.47,-.01,;1.7,1.32,;.79,2.56,;-.67,2.09,;-2.01,2.86,;-2.01,4.4,;-3.34,5.17,;-4.67,4.4,;-4.67,2.86,;-3.34,2.09,;-6.01,5.17,;-6.01,6.71,;-7.34,7.48,;-8.68,6.71,;-8.68,5.17,;-7.34,4.4,;-.67,.55,;-1.92,-.36,;.79,.07,;1.27,-1.39,;.24,-2.54,;-1.23,-3.01,;-.08,-4.04,;2.47,2.65,;4.01,2.65,;6.11,.55,;6.11,-.99,;7.44,-1.76,;8.78,-.99,;8.78,.55,;7.44,1.32,)|
Structure:
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