Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464637
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
63.0±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464637
Synonyms:
CIS-8-Dimethylamino-1,3-bis(2-methylsulfonyl-ethyl)-8-phenyl-1,3- diazaspiro[4.5]decan-2-one | US10793556, Example SC_4066 | US10793556, Example SC_4067 | US10793556, Example SC_4068 | US10793556, Example SC_4069 | US10793556, Example SC_4070 | US10793556, Example SC_4071
Type:
Small organic molecule
Emp. Form.:
C30H42N6O
Mol. Mass.:
502.6941
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1 |r,wU:6.26,3.2,(7.97,7.93,;6.48,8.33,;6.48,9.87,;5.39,7.24,;4.62,5.91,;3.08,5.91,;2.31,7.24,;1.41,8.49,;-.06,8.01,;-1.39,8.78,;-2.72,8.01,;-4.06,8.78,;-5.39,8.01,;-5.39,6.47,;-4.06,5.7,;-2.72,6.47,;-6.73,5.7,;-8.06,6.47,;-9.39,5.7,;-9.39,4.16,;-8.06,3.39,;-6.73,4.16,;-.06,6.47,;-1.3,5.56,;1.41,5.99,;1.88,4.53,;.85,3.38,;-.61,2.91,;.53,1.88,;3.08,8.57,;4.62,8.57,;6.73,6.47,;6.73,4.93,;8.06,4.16,;9.39,4.93,;9.39,6.47,;8.06,7.24,)|
Structure:
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