Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464650
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
415±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464650
Synonyms:
CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(2-oxo-2-pyrrolidin-1-yl- ethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4077 | US10793556, Example SC_4078 | US10793556, Example SC_4079 | US10793556, Example SC_4080 | US10793556, Example SC_4081 | US10793556, Example SC_4082
Type:
Small organic molecule
Emp. Form.:
C28H43N3O5S
Mol. Mass.:
533.723
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(5.35,6.14,;3.81,6.14,;3.04,7.47,;3.04,4.8,;2.27,3.47,;.73,3.47,;-.04,4.8,;-.95,6.05,;-2.41,5.57,;-3.74,6.34,;-5.08,5.57,;-6.41,6.34,;-7.74,5.57,;-5.08,7.11,;-5.08,8.65,;-6.41,9.42,;-7.18,10.76,;-5.64,10.76,;-7.74,8.65,;-7.74,7.11,;-2.41,4.03,;-3.66,3.13,;-.95,3.56,;-.47,2.09,;-1.5,.95,;-.01,.55,;-3.04,.95,;-3.04,-.59,;-1.5,-.59,;.73,6.14,;2.27,6.14,;3.81,3.47,;3.04,2.13,;3.81,.8,;5.35,.8,;6.12,2.13,;5.35,3.47,)|
Structure:
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