Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464656
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
935±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464656
Synonyms:
CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-methyl]-3-[2-(3-hydroxy-oxetan- 3-yl)-ethyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4083 | US10793556, Example SC_4084 | US10793556, Example SC_4085 | US10793556, Example SC_4086 | US10793556, Example SC_4087 | US10793556, Example SC_4088
Type:
Small organic molecule
Emp. Form.:
C26H42N4O4S
Mol. Mass.:
506.701
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:6.20,3.2,(5.7,-1.23,;4.16,-1.23,;3.39,.1,;3.39,-2.57,;2.62,-3.9,;1.08,-3.9,;.31,-2.57,;-.59,-1.32,;-2.06,-1.8,;-3.39,-1.03,;-4.73,-1.8,;-5.5,-3.13,;-3.96,-3.13,;-6.06,-1.03,;-7.39,-1.8,;-8.73,-1.03,;-8.16,-3.13,;-6.62,-3.13,;-2.06,-3.34,;-3.3,-4.24,;-.59,-3.81,;-.12,-5.28,;-1.15,-6.42,;.34,-6.82,;-2.69,-6.42,;-2.69,-7.96,;-1.15,-7.96,;1.08,-1.23,;2.62,-1.23,;4.16,-3.9,;3.39,-5.23,;4.16,-6.57,;5.7,-6.57,;6.47,-5.23,;5.7,-3.9,)|
Structure:
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