Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464667
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
1980±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464667
Synonyms:
CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-(3-fluorophenyl)-3-[(4-hydroxy- tetrahydro-pyran-4-yl)-methyl]-1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4094 | US10793556, Example SC_4095
Type:
Small organic molecule
Emp. Form.:
C30H42N6O2
Mol. Mass.:
518.6935
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:6.25,3.2,(6.12,15.6,;6.12,14.06,;7.61,13.66,;5.04,12.97,;4.27,11.63,;2.73,11.63,;1.96,12.97,;1.05,14.21,;-.41,13.74,;-1.75,14.51,;-1.75,16.05,;-3.08,16.82,;-4.42,16.05,;-4.42,14.51,;-3.08,13.74,;-5.75,16.82,;-5.75,18.36,;-7.08,19.13,;-8.42,18.36,;-8.42,16.82,;-7.08,16.05,;-.41,12.2,;-1.66,11.29,;1.05,11.72,;1.53,10.26,;.5,9.11,;1.98,8.71,;-1.04,9.11,;-1.04,7.57,;.5,7.57,;2.73,14.3,;4.27,14.3,;6.37,12.2,;6.37,10.66,;7.7,9.89,;9.04,10.66,;9.04,12.2,;7.7,12.97,)|
Structure:
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