Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM464669
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
395±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM464669
Synonyms:
CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-phenyl-3-(1-pyridazin-4-yl- pipendrin-4-yl)-1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4096 | US10793556, Example SC_4097 | US10793556, Example SC_4098
Type:
Small organic molecule
Emp. Form.:
C27H40FN3O5S
Mol. Mass.:
537.687
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1cccc(F)c1 |r,wU:6.22,3.2,(4.57,-1.94,;4.57,-3.48,;6.05,-3.88,;3.48,-4.57,;2.71,-5.91,;1.17,-5.91,;.4,-4.57,;-.51,-3.33,;-1.97,-3.8,;-3.31,-3.03,;-4.64,-3.8,;-4.64,-2.26,;-5.97,-3.03,;-7.31,-3.8,;-7.31,-5.34,;-8.8,-4.94,;-7.71,-6.83,;-5.97,-6.11,;-4.64,-5.34,;-1.97,-5.34,;-3.22,-6.25,;-.51,-5.82,;-.03,-7.28,;-1.06,-8.43,;.42,-8.83,;-2.6,-8.43,;-2.6,-9.97,;-1.06,-9.97,;1.17,-3.24,;2.71,-3.24,;4.81,-5.34,;4.81,-6.88,;6.14,-7.65,;7.48,-6.88,;7.48,-5.34,;8.81,-4.57,;6.14,-4.57,)|
Structure:
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