Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM464672
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
690±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM464672
Synonyms:
CIS-3-[8-(Ethyl-methyl-amino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]- 2,2-dimethyl-propionitrile | US10793556, Example SC_5061 | US10793556, Example SC_5062 | US10793556, Example SC_5063
Type:
Small organic molecule
Emp. Form.:
C25H35FN4O
Mol. Mass.:
426.57
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2(F)CC2)CC1)c1ccccc1 |r,wU:6.17,3.2,(5.89,19.14,;4.4,19.54,;4.01,21.03,;3.31,18.45,;2.54,17.12,;1,17.12,;.23,18.45,;-.67,19.7,;-2.13,19.22,;-3.47,19.99,;-4.8,19.22,;-5.57,17.89,;-4.03,17.89,;-5.89,20.31,;-6.98,21.4,;-2.13,17.68,;-3.38,16.78,;-.67,17.2,;-.19,15.74,;-1.22,14.6,;.26,14.2,;-2.69,14.12,;-1.55,13.09,;1,19.78,;2.54,19.78,;4.4,17.36,;4.01,15.87,;5.09,14.79,;6.58,15.18,;6.98,16.67,;5.89,17.76,)|
Structure:
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