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Target
Mu-type opioid receptor
Ligand
BDBM464675
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
230±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464675
Synonyms:
CIS-3-[1-(Cyclopropyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-2,2-dimethyl-propionitrile | US10793556, Example SC_5075 | US10793556, Example SC_5080
Type:
Small organic molecule
Emp. Form.:
C25H36N4O
Mol. Mass.:
408.5795
SMILES:
CN(C)[C@@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2CC2)CC1)c1ccccc1 |r,wU:3.2,wD:6.17,(6.05,-3.09,;4.56,-2.69,;4.16,-1.2,;3.47,-3.78,;2.7,-2.45,;1.16,-2.45,;.39,-3.78,;-.51,-2.54,;-1.98,-3.01,;-3.22,-2.11,;-4.63,-2.73,;-4.23,-4.22,;-5.4,-4.07,;-5.88,-1.83,;-7.14,-.93,;-1.98,-4.55,;-3.22,-5.46,;-.51,-5.03,;-.04,-6.49,;-1.07,-7.64,;-2.53,-8.11,;-1.39,-9.14,;1.16,-5.12,;2.7,-5.12,;4.56,-4.87,;4.16,-6.36,;5.25,-7.45,;6.74,-7.05,;7.14,-5.56,;6.05,-4.47,)|
Structure:
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