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Target
Tyrosine-protein kinase BTK
Ligand
BDBM444718
Substrate
n/a
Meas. Tech.
Kinases Assay
IC50
55±n/a nM
Citation
 Liao, X; Li, J; Lu, Z; Zhou, Y; Gao, A Bruton's tyrosine kinase inhibitors US Patent  US10793566 Publication Date 10/6/2020 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM444718
Synonyms:
(R)-1-(3-(3-(4-(3-methoxy-2- propoxyphenoxy)phenyl)-7-propoxy- 1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-1- yl)prop-2-en-1-one | US10662187, Compound 88 | US10793566, Compound 88
Type:
Small organic molecule
Emp. Form.:
C33H38N4O5
Mol. Mass.:
570.6786
SMILES:
CCCOc1cncc2c(nn(C3CCCN(C3)C(=O)C=C)c12)-c1ccc(Oc2cccc(OC)c2OCCC)cc1
Structure:
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