Reaction Details Report a problem with these data
Target
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Ligand
BDBM399702
Substrate
n/a
Meas. Tech.
TYK2 JH2 Domain Binding Assay
Kd
>10±n/a nM
Citation
 Greenwood, JR; Harriman, GC; Leit de Moradei, SM; Masse, CE; McLean, TH; Mondal, S TYK2 inhibitors and uses thereof US Patent  US10793574 Publication Date 10/6/2020 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
36941.98
Organism:
Homo sapiens (Human)
Description:
P29597 (aa 556-888)
Residue:
333
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
  
Inhibitor
Name:
BDBM399702
Synonyms:
US10323036, Compound I-146 | US10793574, Compound I-146 | US11220508, Compound I-146
Type:
Small organic molecule
Emp. Form.:
C22H19ClN8O2
Mol. Mass.:
462.892
SMILES:
COc1c(Cl)cccc1Nc1cc(Nc2cnc(C3CC3)c(n2)C#N)nc2[nH]n(C)c(=O)c12
Structure:
Search PDB for entries with ligand similarity: