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Target
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Ligand
BDBM399762
Substrate
n/a
Meas. Tech.
TYK2 JH2 Domain Binding Assay
Kd
5.5±n/a nM
Citation
 Greenwood, JR; Harriman, GC; Leit de Moradei, SM; Masse, CE; McLean, TH; Mondal, S TYK2 inhibitors and uses thereof US Patent  US10793574 Publication Date 10/6/2020 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
36941.98
Organism:
Homo sapiens (Human)
Description:
P29597 (aa 556-888)
Residue:
333
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
  
Inhibitor
Name:
BDBM399762
Synonyms:
US10323036, Compound VIII-10 | US10793574, Compound VIII-10 | US11220508, Compound VIII-10
Type:
Small organic molecule
Emp. Form.:
C23H24N8O3
Mol. Mass.:
460.4885
SMILES:
COc1c(Nc2cc(NC(=O)C3CC3)ncc2-n2cc(CO)cn2)cccc1-c1ncn(C)n1
Structure:
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