Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM403039
Substrate
n/a
Meas. Tech.
Enzymatic DELFIA Assay
IC50
1.10±n/a nM
Citation
 Trzupek, JDLee, KLBunnage, MEHan, SHepworth, DLovering, FEMathias, JPPapaioannou, NPierce, BSStrohbach, JWWright, SWZapf, CWGavrin, LKLee, AAnderson, DRCurran, KJDehnhardt, CMSaiah, EGoldberg, JAWang, XHuang, HVargas, RLowe, MDPatny, A Bicyclic-fused heteroaryl or aryl compounds US Patent  US10793579 Publication Date 10/6/2020 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM403039
Synonyms:
US10329302, Example 187 | US10793579, Example 187 | US11702424, Example 187
Type:
Small organic molecule
Emp. Form.:
C19H22FN3O4
Mol. Mass.:
375.3941
SMILES:
CC(C)Oc1cc2c(OC[C@H]3NC(=O)[C@@H](F)[C@H]3C)nccc2cc1C(N)=O |r|
Structure:
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