Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM403067
Substrate
n/a
Meas. Tech.
Enzymatic DELFIA Assay
IC50
0.900±n/a nM
Citation
 Trzupek, JDLee, KLBunnage, MEHan, SHepworth, DLovering, FEMathias, JPPapaioannou, NPierce, BSStrohbach, JWWright, SWZapf, CWGavrin, LKLee, AAnderson, DRCurran, KJDehnhardt, CMSaiah, EGoldberg, JAWang, XHuang, HVargas, RLowe, MDPatny, A Bicyclic-fused heteroaryl or aryl compounds US Patent  US10793579 Publication Date 10/6/2020 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM403067
Synonyms:
US10329302, Example 220 | US10793579, Example 220 | US11702424, Example 220
Type:
Small organic molecule
Emp. Form.:
C18H18F2N2O4
Mol. Mass.:
364.3433
SMILES:
COc1cc2c(OC[C@H]3NC(=O)[C@H](F)[C@H]3C)ccc(F)c2cc1C(N)=O |r|
Structure:
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