Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Ligand
BDBM466058
Substrate
n/a
Meas. Tech.
PDE4 Assay
IC50
<100±n/a nM
Citation
 Liang, XLarsen, J Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors US Patent  US10793580 Publication Date 10/6/2020 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D
Type:
Protein
Mol. Mass.:
91092.69
Organism:
Homo sapiens (Human)
Description:
Q08499
Residue:
809
Sequence:
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
  
Inhibitor
Name:
BDBM466058
Synonyms:
US10793580, Example 159 | [(2R)-3-(1-ethyl-8-oxo- spiro[6,7-dihydro-4H- pyrazolo[3,4-c]azepine-5,4'- tetrahydropyran]-3-yl)-2- methyl-propyl] 3- isopropylsulfonylbenzoate
Type:
Small organic molecule
Emp. Form.:
C27H37N3O6S
Mol. Mass.:
531.664
SMILES:
CCn1nc(C[C@@H](C)COC(=O)c2cccc(c2)S(=O)(=O)C(C)C)c2CC3(CCOCC3)CNC(=O)c12 |r|
Structure:
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