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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Ligand
BDBM466108
Substrate
n/a
Meas. Tech.
PDE4 Assay
IC50
<100±n/a nM
Citation
 Liang, X; Larsen, J Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors US Patent  US10793580 Publication Date 10/6/2020 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D
Type:
Protein
Mol. Mass.:
91092.69
Organism:
Homo sapiens (Human)
Description:
Q08499
Residue:
809
Sequence:
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
  
Inhibitor
Name:
BDBM466108
Synonyms:
US10793580, Example 208 | [3-(1-ethyl-8-oxo-spiro- [6,7-dihydro-4H-pyrazolo- [3,4-c]azepine-5,4'-tetra- hydropyran]-3-yl)-2,2- dimethyl-propyl] 4-(di- methylsulfamoyl)benzoate
Type:
Small organic molecule
Emp. Form.:
C27H38N4O6S
Mol. Mass.:
546.679
SMILES:
CCn1nc(CC(C)(C)COC(=O)c2ccc(cc2)S(=O)(=O)N(C)C)c2CC3(CCOCC3)CNC(=O)c12
Structure:
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