Target
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Ligand
BDBM466267
Substrate
n/a
Meas. Tech.
Inhibitory Assay
IC50
240±n/a nM
Citation
 Okuyama, MFukunaga, KUsui, KHayashi, NIijima, DHoriuchi, HFujimoto, N Bicyclic heterocyclic compound US Patent  US10793582 Publication Date 10/6/2020 
Target
Name:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:
2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:
Enzyme
Mol. Mass.:
47353.09
Organism:
Homo sapiens (Human)
Description:
Q8N5Z0
Residue:
425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL
  
Inhibitor
Name:
BDBM466267
Synonyms:
(S)—N-benzyl-3-(7-cyclopropyl[1,3]thiazolo[4,5-d]pyrimidin-2-yl)-1,3-thiazolidine-4-carboxamide | US10793582, Example 100
Type:
Small organic molecule
Emp. Form.:
C19H19N5OS2
Mol. Mass.:
397.517
SMILES:
O=C(NCc1ccccc1)[C@H]1CSCN1c1nc2ncnc(C3CC3)c2s1 |r|
Structure:
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