Target
Genome polyprotein [1973-2419]
Ligand
BDBM466315
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Beigelman, LWang, GSmith, DB Substituted nucleosides, nucleotides and analogs thereof US Patent  US10793591 Publication Date 10/6/2020 
Target
Name:
Genome polyprotein [1973-2419]
Synonyms:
Non-structural protein 5A (NS5A) | POLG_HCVCO | RNA-directed RNA polymerase (NS5B)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48705.67
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
Q9WMX2[1973-2419]
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCC
  
Inhibitor
Name:
BDBM466315
Synonyms:
US10793591, Compound 15
Type:
Small organic molecule
Emp. Form.:
C12H17FN5O14P3
Mol. Mass.:
567.2082
SMILES:
NC1=NC2C(N=CN2[C@@H]2O[C@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@]2(O)C#C)C(=O)N1 |r,c:5,t:1|
Structure:
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