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Target
N-formyl peptide receptor 2
Ligand
BDBM350578
Substrate
n/a
Meas. Tech.
FLIPR
EC50
103±n/a nM
Citation
 Viswanath, V; Beard, RL; Donello, JE; Hsia, E Use of agonists of formyl peptide receptor 2 for treating dermatological diseases US Patent  US10799518 Publication Date 10/13/2020 
Target
Name:
N-formyl peptide receptor 2
Synonyms:
ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38968.35
Organism:
Homo sapiens (Human)
Description:
P25090
Residue:
351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
  
Inhibitor
Name:
BDBM350578
Synonyms:
(+) tert-butyl {3-[(3R)-3-(4- cyanophenyl)-7-({[4- (methylsulfinyl)phenyl] carbamoyl}amino)-1-oxo- 3,4-dihydroisoquinolin-2(1H)-yl] propyl}carbamate | US10208071, Compound 40 | US10434112, Compound 40 | US10799518, Compound 40
Type:
Small organic molecule
Emp. Form.:
C32H35N5O5S
Mol. Mass.:
601.716
SMILES:
CS(=O)c1ccc(NC(=O)Nc2ccc3CC(N(CCCNC(=O)OC(C)(C)C)C(=O)c3c2)c2ccc(cc2)C#N)cc1
Structure:
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