Target
DNA-directed RNA polymerase subunit alpha
Ligand
BDBM466508
Substrate
n/a
Meas. Tech.
Assay of Inhibition of Staphylococcus Aureus RNA Polymerase
IC50
>400000±n/a nM
Citation
 Ebright, RHShen, J Arylpropionyl-triketone antibacterial agents US Patent  US10800725 Publication Date 10/13/2020 
Target
Name:
DNA-directed RNA polymerase subunit alpha
Synonyms:
RNA polymerase subunit alpha | RNAP subunit alpha | RPOA_STAAN | Transcriptase subunit alpha | rpoA
Type:
Protein
Mol. Mass.:
34991.14
Organism:
n/a
Description:
P66706
Residue:
314
Sequence:
MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED
 
Inhibitor
Name:
BDBM466508
Synonyms:
US10800725, Compound 16
Type:
Small organic molecule
Emp. Form.:
C21H26O4
Mol. Mass.:
342.4287
SMILES:
CCC1=C(O)C(CC)(CC)C(=O)C(C(=O)CCc2ccccc2)=C1O |c:2,23|
Structure:
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