Reaction Details Report a problem with these data
Target
DNA-directed RNA polymerase subunit alpha
Ligand
BDBM466509
Substrate
n/a
Meas. Tech.
Assay of Inhibition of Escherichia coli RNA Polymerase
IC50
70000±n/a nM
Citation
 Ebright, RH; Shen, J Arylpropionyl-triketone antibacterial agents US Patent  US10800725 Publication Date 10/13/2020 
Target
Name:
DNA-directed RNA polymerase subunit alpha
Synonyms:
JW3257 | RNA polymerase subunit alpha | RNAP subunit alpha | RPOA_ECOLI | Transcriptase subunit alpha | pez | phs | rpoA | sez
Type:
PROTEIN
Mol. Mass.:
36497.18
Organism:
Escherichia coli K-12
Description:
ChEMBL_106172
Residue:
329
Sequence:
MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLRDVRQPEVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIADE
  
Inhibitor
Name:
BDBM466509
Synonyms:
US10800725, Compound 17
Type:
Small organic molecule
Emp. Form.:
C24H32O4
Mol. Mass.:
384.5085
SMILES:
CCCC1=C(O)C(CCC)(CCC)C(=O)C(C(=O)CCc2ccccc2)=C1O |c:3,26|
Structure:
Search PDB for entries with ligand similarity: