Reaction Details
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DNA-directed RNA polymerase subunit alpha
Ligand
BDBM466520
Substrate
n/a
Meas. Tech.
Assay of Inhibition of Staphylococcus Aureus RNA Polymerase
IC50
2200±n/a nM
Citation
Ebright, RH; Shen, J Arylpropionyl-triketone antibacterial agents US Patent US10800725 Publication Date 10/13/2020 More Info.:
Target
Name:
DNA-directed RNA polymerase subunit alpha
Synonyms:
RNA polymerase subunit alpha | RNAP subunit alpha | RPOA_STAAN | Transcriptase subunit alpha | rpoA
Type:
Protein
Mol. Mass.:
34991.14
Organism:
n/a
Description:
P66706
Residue:
314
Sequence:
MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED
Inhibitor
Name:
BDBM466520
Synonyms:
US10800725, Compound 8
Type:
Small organic molecule
Emp. Form.:
C31H46O4
Mol. Mass.:
482.6945
SMILES:
CC(C)CCC1=C(O)C(CCC(C)C)(CCC(C)C)C(=O)C(C(=O)CCc2cccc(C)c2)=C1O |c:5,33|
Structure:
