Reaction Details Report a problem with these data
Target
4-aminobutyrate aminotransferase, mitochondrial
Ligand
BDBM323800
Substrate
n/a
Meas. Tech.
Evaluation of Compounds as Inhibitors of GABA-AT
Ki
2230000±n/a nM
Citation
 Silverman, RB; Le, HV; Hawker, DD Tetrahydrothiophene-based GABA aminotransferase inactivators and analogs thereof for treating neurological disorders US Patent  US10800753 Publication Date 10/13/2020 
Target
Name:
4-aminobutyrate aminotransferase, mitochondrial
Synonyms:
(S)-3-amino-2-methylpropionate transaminase | 4-aminobutyrate aminotransferase, mitochondrial | ABAT | GABA aminotransferase | GABA transaminase | GABA-AT | GABA-T | GABAT | GABT_HUMAN | Gamma-amino-N-butyrate transaminase | L-AIBAT
Type:
PROTEIN
Mol. Mass.:
56449.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459248
Residue:
500
Sequence:
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK
  
Inhibitor
Name:
BDBM323800
Synonyms:
(2R,4S)-4-Aminotetrahydrothiophene-2-carboxylic acid | US10189807, Compound 18 | US10800753, Compound 18
Type:
Small organic molecule
Emp. Form.:
C5H9NO2S
Mol. Mass.:
147.195
SMILES:
N[C@@H]1CS[C@H](C1)C(O)=O
Structure:
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