Target
Short transient receptor potential channel 6
Ligand
BDBM466616
Substrate
n/a
Meas. Tech.
High Throughput Screening Assay
IC50
130±n/a nM
Citation
 Bouyssou, TGottschling, DHeine, NKeenan, LLLowe, MDRazavi, HSarko, CRSurprenant, STakahashi, HTurner, MRWu, X Inhibitors of TRPC6 US Patent  US10800757 Publication Date 10/13/2020 
Target
Name:
Short transient receptor potential channel 6
Synonyms:
TRP-6 | TRP6 | TRPC6 | TRPC6_HUMAN | Transient receptor protein 6
Type:
PROTEIN
Mol. Mass.:
106326.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107640
Residue:
931
Sequence:
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR
  
Inhibitor
Name:
BDBM466616
Synonyms:
(6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,4']bipyridinyl-1'-yl)- [5-(4-fluoro-benzyloxy)-4-methoxy- pyridin-2-yl]-methanone | US10800757, Compound 32 | US10889568, Compound 32
Type:
Small organic molecule
Emp. Form.:
C25H27FN4O4
Mol. Mass.:
466.5047
SMILES:
COc1cc(ncc1OCc1ccc(F)cc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Structure:
Search PDB for entries with ligand similarity: