Target
Short transient receptor potential channel 6
Ligand
BDBM466645
Substrate
n/a
Meas. Tech.
High Throughput Screening Assay
IC50
500±n/a nM
Citation
 Bouyssou, TGottschling, DHeine, NKeenan, LLLowe, MDRazavi, HSarko, CRSurprenant, STakahashi, HTurner, MRWu, X Inhibitors of TRPC6 US Patent  US10800757 Publication Date 10/13/2020 
Target
Name:
Short transient receptor potential channel 6
Synonyms:
TRP-6 | TRP6 | TRPC6 | TRPC6_HUMAN | Transient receptor protein 6
Type:
PROTEIN
Mol. Mass.:
106326.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107640
Residue:
931
Sequence:
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR
  
Inhibitor
Name:
BDBM466645
Synonyms:
US10800757, Compound 61 | US10889568, Compound 61 | [4-(6-Amino-4-methoxy-pyridin-3-yl)- piperazin-1-yl]-(5- cyclopropylmethoxy-4-methoxy- pyridin-2-yl)-methanone
Type:
Small organic molecule
Emp. Form.:
C21H27N5O4
Mol. Mass.:
413.4702
SMILES:
COc1cc(ncc1OCC1CC1)C(=O)N1CCN(CC1)c1cnc(N)cc1OC
Structure:
Search PDB for entries with ligand similarity: